In the unit vial, sterile amoxicillin sodium that is equal to 2.5 g amoxicillin activity is available. With each vial, 10 ml sterile, apirogene injection bidistiled water-containing ampoule is available. When the per vial is diluted with 10 ml solvent ampoule, Each Icc of the composing clear, 12 ml solution contains approximately 208 mg amoxicillin.

 

 

 

Amoxicillin (a –amino –p -hydroxybenzykpenicillin) is a semi synthetic penicillin having strong area of effect as well as strong bactericide impact, and having close relationship and similar spectrum with ampicilline (a- aminobenzylpenicilin). It has much larger spectrum compared to penicillin. The bacteria are effective by inhibiting the mucopeptide biosynthesis of the cell wall. Its antibacterial effect is faster and superior than ampicilline. It has a bactericidal effect against many of the gram- positive and gram- negative bacteria that are broadly available. Its effect on the gram positive bacteria is higher than ampicilline. Sensitivity of the bacteria toward amoxicillin is as follows:
Sensitive bacteria: Mainly gram- positive bacteria containing the beta haemolytic Streptococcus sp's (Strep. Agalactiae, S. canis, S. zooepidemicsus, S. dysgalactiae, S. suis, S. uberis, Bacillus anthracis, Actinomyces sp., mainly Corynebacter sp., Erysipelothrix rhusiopathise, mainly Listeria monocytogenes) some anaerobes (Clostridium sp., mainly Fusobacterium sp., some Bacteroidees sp.) some gram negative aerobes (Haemophilus somnus), Borrelia sp., Leptospira sp., Actinobacillus sp., Haemophilus sp., Moraxella sp., Pasteuralla sp.,
Middle- level sensitive bacteria: while they change together with the gained immunity, these bacteria species are middle- level sensitive: Actinobacillus sp., Borrelia sp., Haemophilus sp., Leptospira sp., Moraxella sp., Pasteurella sp., Proteus sp., Taylorella equigeniitalis, Serpulina sp., Campylobacter sp., Enterococci., and Rhodococcus equi. Development of resistance is widely encountered in Enterobacteriaceae.
Resistant bacteria: Bacteroides fragilis, Bordetella bronchiseptica, Citrobacter sp. Enterobacter sp., Klebsiella sp., other Proteus sp., Pseudomonas aeroginosa, Serratia sp., Yersinia enterocolitica.
Amoxicillin, subsequent to the in-muscle application, is absorbed fast. When. Except for the inflation of the meninx, it immediately diffuses in many of the body's tissues and fluids other than brain and spinal fluid. It disperses into all the tissue and bronchus secretions. Much of the amoxicillin is discharged by urine without modification. Since it is discharged in the urine in active form and since it enters the enterohepatic siklus, its effects on the urinary tract and intestine infections is at maximum level. Amoxicillin, subsequent to its parental application, reaches at a concentration that is two times higher than ampicilline. Amoxicillin has 40 % higher half- life than ampicilline.


 

Amoxicillin is used for the treatment in horse, cattle, goats, sheep, dogs, and cats against the infections of digestion system, respiratory system, urinary tract and genital system resulting from bacteria, skin and soft tissue infections as well as the bacterial infections proceeding with the viral infections caused by bacteria.

 

 

In the cases that it is not recommended by the veterinary otherwise, following dose chart is applied.
Daily dose of the Alfoxil 2.5 g Injection Solution is averagely 7.5 – 10 mg being proportional to the body weight. In the practical applications, for horse, cattle, goats, sheep, 1.8 – 2.4 cc for 50 kg live weight, and in cats and dogs, 0.2 – 0.25 cc for 5 kg live weight is applied into the muscle.
It is sufficient that Alfoxil 2.5 g Injection Solution is applied once a day for a 5- day period. It must never be applied by intravenous method.

 

 

It has been put on the market 1 transparent vial containing amoxicillin sodium that is equal to 2,5 gr amoxicillin, together with 1 transparent ampoule containing 10 ml solvent in carton boxes.

 

 
 
 
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